Oligonucleotidecyclization: the thiol-maleimide reaction revisited
نویسندگان
چکیده
منابع مشابه
Oligonucleotide cyclization: the thiol-maleimide reaction revisited.
A novel method to synthesize cyclic oligonucleotides (5- to 26-mer) using the thiol-maleimide reaction is described. The target molecules were obtained after subsequent removal of thiol and maleimide protecting groups from 5'-maleimido-3'-thiol-derivatized linear precursors. Retro-Diels-Alder conditions deprotecting the maleimide simultaneously promoted cyclization cleanly and in high yield.
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ژورنال
عنوان ژورنال: Chem. Commun.
سال: 2013
ISSN: 1359-7345,1364-548X
DOI: 10.1039/c2cc35357a